What comics (including webcomics) have the most distinctive art?
Nancy.
Transmetropolitan, though I have a hard time deciding whether is it the style or the characters. Probably both.
Knights of Sidonia was drawn by an architect. Definitely shows - thel background / landscape shots are quite ridiculously good and give you the scope a lot of comics tend to miss.
Darick Robertson’s art is always great.
Nsfw: oglaf.com
Order of the Stick
Moebius
God this is gold
Quino.
Sonichu
For anyone who doesn’t know, this is one of those internet rabbit holes from which not even light can escape.
XKCD
The great thing about Perry Bible Fellowship is that the varying art styles help tell the story.
The DaneMen
Unix Surrealism
I personally think the art style is very distinctive compared to just about anything else I’ve seen.
The Other End Comics
Extra Fabulous Comics
Romantically Apocalyptic sticks out in my mind.