https://en.wikipedia.org/wiki/Panama_Canal

Great Britain attempted to develop a canal in 1843. According to the New-York Daily Tribune, 24 August 1843, Barings Bank of London and the Republic of New Granada entered into a contract for the construction of a canal across the Isthmus of Darien (Isthmus of Panama). They referred to it as the Atlantic and Pacific Canal, and it was a wholly British endeavor. Projected for completion in five years, the plan was never carried out. At nearly the same time, other ideas were floated, including a canal (and/or a railroad) across Mexico’s Isthmus of Tehuantepec. That did not develop, either.[9]

In 1846, the Mallarino–Bidlack Treaty, negotiated between the US and New Granada, granted the United States transit rights and the right to intervene militarily in the isthmus. In 1848, the discovery of gold in California, on the West Coast of the United States, generated renewed interest in a canal crossing between the Atlantic and Pacific oceans.

https://en.wikipedia.org/wiki/Mallarino–Bidlack_Treaty

Officially, it was entitled Tratado de Paz, Amistad, Navegación y Comercio (Treaty of Peace, Friendship, Commerce and Navigation), and was meant to represent an agreement of mutual cooperation. It granted the U.S. significant transit rights over the Panamanian isthmus, as well as military powers to suppress social conflicts and independence struggles targeted against Colombia. Under the Bidlack-Mallarino Treaty, the U.S. intervened militarily many times on the isthmus, usually against civilians, peasant guerrillas, or Liberal Party independence struggles. After the beginning of the California Gold Rush of 1848, the U.S. spent seven years constructing a trans-isthmian Panama Railway. The result of the treaty, however, was to give the United States a legal opening in politically and economically influencing the Panama isthmus, which was part of New Granada at the time, but was later to become the independent country of Panama in accordance with the wishes of the United States. In 1903, however, the United States failed to gain access to a strip on the isthmus for the construction of a canal, and reversed its position on Panamanian secession from the Republic of Colombia.

https://en.wikipedia.org/wiki/Panama–United_States_relations

The evolution of the relation between Panama and the USA has followed the pattern of a Panamanian project for the recovering of the territory of the Canal of Panama, a project which became public after the events of May 21, 1958, November 3, 1959, and then on January 9, 1964. The latter day is known in Panama as the Martyrs’ Day (Panama), in which a riot over the right to raise the Panamanian flag in an American school became the vicinity of the Panama Canal.

The following years saw a lengthy negotiation process with the United States, culminating with the Torrijos–Carter Treaties, in which the transfer of the Panama Canal to Panama was set to be completed in December, 1999. The process of transition, however, was made difficult by the existence of the de facto military rule of Manuel Noriega in Panama from 1982 to 1989.

https://en.wikipedia.org/wiki/United_States_invasion_of_Panama

The United States invaded Panama in mid-December 1989 during the presidency of George H. W. Bush. The stated purpose of the invasion was to depose the de facto ruler of Panama, General Manuel Noriega, who was wanted by U.S. authorities for racketeering and drug trafficking. The operation, codenamed Operation Just Cause, concluded in late January 1990 with the surrender of Noriega.[9] The Panama Defense Forces (PDF) were dissolved, and President-elect Guillermo Endara was sworn into office.

Noriega, who had longstanding ties to United States intelligence agencies, consolidated power to become Panama’s de facto dictator in the early 1980s. In the mid-1980s, relations between Noriega and the U.S. began to deteriorate due to fallout of the murder of Hugo Spadafora and the removal from office of President Nicolas Ardito Barletta. His criminal activities and association with other spy agencies came to light, and in 1988 he was indicted by federal grand juries on several drug-related charges. Negotiations seeking his resignation, which began under the presidency of Ronald Reagan, were ultimately unsuccessful. In 1989, Noriega annulled the results of the Panamanian general elections, which appeared to have been won by opposition candidate Guillermo Endara; President Bush responded by reinforcing the U.S. garrison in the Canal Zone. After a U.S. Marine officer was shot dead at a PDF roadblock, Bush authorized the execution of the Panama invasion plan.

The history of Panama and the US in general and the Canal in particular is riddled with the US meddling violently in the affairs of Panama and suppressing its people on the behalf of US aligned dictators.